Endocrine Abstracts

Introduction: Prolactin is a hormone which is characterized with a high structural and functional polymorphism. Macroprolactin is one of the form of prolactin - it is a complex of monomeric prolactin and immunoglobulin. Macroprolactin is characterized with immunoreactivity and probably the lack of biological activity.Purpose: The main purpose of our study was to estimate the frequency of macroprolactin appearance among the patients with hyperpronactinaem...

Introduction: Undetectable concentration of Tg after rhTSH stimulation (Tg/rhTSH) is one of the most important criteria in evaluating the effectiveness of radioiodine ablation in patients with differentiated thyroid cancer (DTC) treated with 131I.Aim: To evaluate the possibility of using L-T4 suppression treatment (Tg/L-T4) measurements by the ultrasensitive method TRACE (immunofluorescence method) with the KRYPTOR analyzer instead of the Tg/rhTSH measur...

Introduction: Postoperative thyroglobulin (TgPO) has a well established position as the prognostic factor for the follow-up of patients with differentiated thyroid cancer (DTC) after total thyroidectomy. However, the presence of thyroid remnants after surgery may diminish predictive value of TgPO.The aim of the study is to evaluate prognostic value of stimulated postablative thyroglobulin level (TgPA) measured after 6–9 months after radioacitve iodi...

Introduction: The correct 25-hydroxy vitamin D (25(OH)D) level plays a key role in the proper supply of vitamin D for the organism. Vitamin D deficiency may lead to an increased risk of development of various neoplasms, including papillary thyroid carcinoma (PTC).Aim: Evaluation of the prevalence of vitamin D deficiency in patients with PTC and analysis of the relation between 25(OH)D levels and age, sex, place of living, severity of the disease, and pre...

The pentagastrin-stimulated calcitonin test is known and widely used in monitoring patients with MTC. Given the problems of pentagastrin availability other diagnostic tests are being tried.The goal of the study was the evaluation of safety and tolerance of high-dose calcium to stimulate calcitonin in MTC patients.Materials: The study included 41 patients after surgery for medullary thyroid cancer who were under observation. Patient...

Introduction: The Pg calcitonin stimulation test is widely used in monitoring patients with MTC. In view of accessibility problems of Pg it is necessary to use high doses of calcium as the calcitonin stimulant.Objective: The aim of the study was the comparison of calcitonin concentrations after Pg and calcium stimulation, respectively.Materials: The study was performed in 31 patients under observation after deemed surgically cured ...

Introduction: Calcitonin is the main MTC marker. However, it has limitations: rapid in vitro degradation, a concentration-dependent biphasic half-life, presence of different isoforms and high cost of a single trial. Other markers of MTC can be procalcitonin and ProGRP.Aim: The aim of the study was to evaluate the diagnostic performance of marking the levels of procalcitonin and ProGRP in monitoring patients with MTC.Material...

Introduction: In ATA recommendations (2016) a delayed risk stratification (DRS) system proposed by D.P. Momesso et al. was accepted as a diagnostic tool for the risk stratification of unfavorable clinical outcome and for monitoring the clinical outcome in differentiated thyroid cancer (DTC) patients treated without radioactive iodine (RAI).The aim of the study: To evaluate the DRS system in patients with low clinical stage (pT1aN0/Nx).<p class="abste...